Americans Vicky (Rebecca Hall) and Cristina (Scarlett Johansson) arrive in Spain for a summer vacation at a friend's (Patricia Clarkson) Barcelona home. Visiting an art gallery, they meet seductive painter Juan Antonio (Javier Bardem), who invites them for a weekend of food, art and sex. Sparks really ignite when his fiery former lover (Penélope Cruz) arrives on the scene, making for a very crowded house.